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Components of the ribosome biogenesis pathway underlie establishment of telomere length set point in Arabidopsis

https://doi.org/10.1038/s41467-019-13448-z

Abdulkina, Liliia R. ; Kobayashi, Callie ; Lovell, John T. ; Chastukhina, Inna B. ; Aklilu, Behailu B. ; Agabekian, Inna A. ; Suescún, Ana V. ; Valeeva, Lia R. ; Nyamsuren, Chuluuntsetseg ; Aglyamova, Galina V. ; et al ( December 2019 , Nature Communications)

Abstract
Telomeres cap the physical ends of eukaryotic chromosomes to ensure complete DNA replication and genome stability. Heritable natural variation in telomere length exists in yeast, mice, plants and humans at birth; however, major effect loci underlying such polymorphism remain elusive. Here, we employ quantitative trait locus (QTL) mapping and transgenic manipulations to identify genes controlling telomere length set point in a multi-parentArabidopsis thalianamapping population. We detect several QTL explaining 63.7% of the total telomere length variation in the Arabidopsis MAGIC population. Loss-of-function mutants of theNOP2Acandidate gene located inside the largest effect QTL and of two other ribosomal genesRPL5AandRPL5Bestablish a shorter telomere length set point than wild type. These findings indicate that evolutionarily conserved components of ribosome biogenesis and cell proliferation pathways promote telomere elongation.

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